Succinate Dehydrogenase
Succinate Dehydrogenase (SDH), also known as electron transport chain complex II, is a vital enzyme involved in both the citric acid cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone in the electron transport chain, which is essential for ATP generation and mitochondrial function. In eukaryotes, SDH is composed of four subunits (SDHA-D), localized to the inner mitochondrial membrane, while in prokaryotes, it is found in the cytoplasmic membrane. SDH deficiency can lead to an abnormal accumulation of succinate, contributing to age-related organ degeneration in tissues expressing SUCNR1. Elevated succinate levels have been linked to skeletal diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. This highlights the importance of SDH in maintaining cellular homeostasis and preventing metabolic disorders[1][2][3].
References:
- [1]. Zhao Y, et al. Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol. 2020 Sep 14;26(34):5074-5089. [Content Brief]
- [2]. Matlac DM, et al. Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas. Front Endocrinol (Lausanne). 2021 Mar 12;12:589451. [Content Brief]
- [3]. Moosavi B, et al. The assembly of succinate dehydrogenase: a key enzyme in bioenergetics. Cell Mol Life Sci. 2019 Oct;76(20):4023-4042. [Content Brief]
All Product Categories
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Succinate Dehydrogenase Related Products (61)
Related Products (61)
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Antibodies (1)
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SDH-IN-44
0 ImagesCat. No.: HY-181346CAS No.: 3103433-67-3SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 12.5 μg/mL against Alternaria solani. SDH-IN-44 exhibits antifungal activity and inhibits fungal mycelial growth. SDH-IN-44 is applicable to research related to fungal infections.
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Antimicrobial agent-51
0 ImagesCat. No.: HY-184420CAS No.: 1822599-86-9Antimicrobial agent-51 is an antifungal agent that increases ROS levels, reduces mitochondrial membrane potential, alters hyphal morphology, and impairs cell membrane integrity. Antimicrobial agent-51 inhibits succinate dehydrogenase (SDH) with an IC50 of 0.76 μg/mL against Colletotrichum gloeosporioides. Antimicrobial agent-51 exhibits control efficacy against Alternaria solani on tomato fruits and shows low toxicity to plant and mammalian cells. Antimicrobial agent-51 can be used for the research of plant fungal diseases.
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SDH-IN-28
0 ImagesCat. No.: HY-174831SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC50 value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC50 values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples.
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Succinate dehydrogenase-IN-10
0 ImagesCat. No.: HY-174456Succinate dehydrogenase-IN-10 (Compound B5) is a RsSDH (Succinate dehydrogenase of R. solani) inhibitor with an IC50 of 0.12 μM. Succinate dehydrogenase-IN-10 exhibits antifungal activity against R. solani (EC50 of 0.002 μg/mL) and P. pachyrhizi.
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Succinate dehydrogenase-IN-7
0 ImagesCat. No.: HY-173021Succinate dehydrogenase-IN-7 (Compound 2f) is a Succinate dehydrogenase inhibitor (IC50 = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity.
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3-Carene (Standard)
0 ImagesCat. No.: HY-N6663RCAS No.: 13466-78-93-Carene (Standard) is the analytical standard of 3-Carene (HY-N6663). This product is intended for research and analytical applications. 3-Carene is an orally active TCA cycle enzyme inhibitor. 3-Carene inhibits succinate dehydrogenase and malate dehydrogenase as well as pyruvate kinase, disrupting energy metabolism. 3-Carene disrupts cell wall and cell membrane integrity, leading to potassium ion leakage, protein leakage, membrane depolarization, ATP depletion, morphological disruption, and cell lysis. 3-Carene interferes with amino acid metabolism, pantothenate and CoA biosynthesis, purine and pyrimidine metabolism, and aminoacyl-tRNA biosynthesis. 3-Carene enhances GABA receptor-mediated synaptic responses. 3-Carene can be used in research on bacterial infections, inflammation, anxiety, and sleep disorders.
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SDH-IN-46
0 ImagesCat. No.: HY-183722SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.
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Succinate dehydrogenase-IN-13
0 ImagesCat. No.: HY-187509Succinate dehydrogenase-IN-13 is a succinate dehydrogenase inhibitor with an IC50 of 8.69 μM against Rhizoctonia solani. Succinate dehydrogenase-IN-13 binds stably within the succinate dehydrogenase active site to disrupt fungal respiration and energy metabolism, and induces hyphal distortion and mitochondrial damage in Rhizoctonia solani. Succinate dehydrogenase-IN-13 reduces intracellular ATP levels in Rhizoctonia solani mycelia. Succinate dehydrogenase-IN-13 can be used for the research of Rhizoctonia solani infection, Botrytis cinerea infection.
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Sitamaquine
0 ImagesCat. No.: HY-19688CAS No.: 57695-04-2Synonyms: WR 6026Sitamaquine (WR 6026) is an orally active Antileishmanial agent and Succinate dehydrogenase inhibitor. Sitamaquine accumulates in the acidocalcisomes of Leishmania, induces organelle alkalization, and crosses the plasma membrane of Leishmania via temperature- and energy-independent diffusion. Sitamaquine disrupts oxidative phosphorylation in Leishmania, induces mitochondrial depolarization, oxidative stress, elevated intracellular calcium, plasma membrane depolarization, and Apoptosis-like cell death. Sitamaquine can be used in the research of leishmaniasis.
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Chloramphenicol succinate sodium (Standard)
0 ImagesCat. No.: HY-N7114ARCAS No.: 982-57-0Chloramphenicol succinate sodium (Standard) is the analytical standard of Chloramphenicol succinate sodium. This product is intended for research and analytical applications. Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease.
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SDH-IN-29
0 ImagesCat. No.: HY-174390CAS No.: 3085095-22-0SDH-IN-29 (Compound A33) is a SDH inhibitor with an IC50 of 0.0709 μM. SDH-IN-29 has a broad spectrum of antifungal activities (EC50s of 0.356, 0.798 and 0.146 μg/mL for Fusarium graminearum, Sclerotinia sclerotiorum, and Rhizoctonia solani, respectively). SDH-IN-29 has moderate to significant protective effects against rice blast, wheat scab and cucumber powdery mildew.
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Succinate dehydrogenase-IN-11
0 ImagesCat. No.: HY-175501Succinate dehydrogenase-IN-11 (Compound A12) is a succinate dehydrogenase inhibitor with an IC50 value of 3.58 μM. Succinate dehydrogenase-IN-11 exhibits antifungal activity. Succinate dehydrogenase-IN-11 shows activity against fungi such as R. solani, B. cinerea, F. graminearum, and S. sclerotiorum in vitro. Succinate dehydrogenase-IN-11 also exerts a controlling effect on R. solani, P. pachyrhizi, and P. sorghi in vivo. Succinate dehydrogenase-IN-11 can be used in research related to antifungal applications.
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SDH-IN-39
0 ImagesCat. No.: HY-178801SDH-IN-39 (Compound A16) is a SDH inhibitor, with an IC50 value of 6.83 μg/mL. SDH-IN-39 is also an antifungal agent. SDH-IN-39 shows antifungal activity against Rhizoctonia solani (EC50 of 1.49 μg/mL), G. zeae, C. gloeosporioides, S. sclerotiorum and M. oryzae.
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Fluxapyroxad (Standard)
0 ImagesFluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
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SDH-IN-37
0 ImagesCat. No.: HY-178799CAS No.: 3085095-58-2SDH-IN-37 (Compound A37) is a potent SDH inhibitor, with an IC50 value of 0.0263 μM. SDH-IN-37 is also an antifungal agent. SDH-IN-37 demonstrates antifungal activities against Rhizoctonia solani, S. sclerotiorum and F. graminearum, with EC50 values of 0.0144, 0.882 and 1.99 μg/mL, respectively.
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Fluindapyr (Standard)
0 ImagesCat. No.: HY-W753375RCAS No.: 1383809-87-7Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.
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Antifungal agent 135
0 ImagesCat. No.: HY-178051Antifungal agent 135 (Compound C2), an antifungal agent, is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 1.99 μM. Antifungal agent 135 has potent antifungal activities against Valsa mali, Sclerotinia sclerotiorum and Phytophthora capsici with EC50 s of 0.280, 1.11 and 0.130 mg/L, respectively. Antifungal agent 135 shows protective and curative activities against Phytophthora capsici and Valsa mali by effectively disrupting hyphal structural integrity and inhibiting mycelial growth.
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SDH-IN-43
0 ImagesCat. No.: HY-W677714CAS No.: 163105-64-4SDH-IN-43 (Compound i-19) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-43 shows potent inhibitory activity against caenorhabditis elegans wirh an IC50 of 6.67 μM. SDH-IN-43 can significantly reduce caenorhabditis elegans reproductive ability and movement ability, and is also effective against drug-resistant strains of Levamisole (HY-A0106), Benzimidazole (HY-Y1825), and Ivermectin (HY-15310). SDH-IN-43 can be used for the research of parasite infection.
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SDH-IN-45
0 ImagesCat. No.: HY-181610CAS No.: 3112883-32-3SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC50 of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.
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SDH-IN-34
0 ImagesCat. No.: HY-178457SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection.
